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In conclusion, the total market size was estimated using a combination of top-down and bottom-up approaches and data triangulation to finalize the market size

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The PK parameters showed dose-proportionality, with a short terminal half-life of 2 hours, a clearance of 0.078 L/h/kg and a volume of distribution at steady-state of 0.22 L/kg

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doi: 10.1136/annrheumdis-2014-205459 60 SchferMMeinerYKekowJBergerSRemstedtSMangerBet al

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